Publications

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Selected Publications:

“Unified, Biosynthesis-Inspired, Completely Stereocontrolled Total Synthesis of All Highest-Order [n + 1] Oligocyclotryptamine Alkaloids.” Scott, T. Z. and Movassaghi, M. J. Am. Chem. Soc. 2024, 146, 23574–23581.

Walker, K. L.; Loach, R. P.; Movassaghi, M. “Total Synthesis of Complex 2,5-Diketopiperazine Alkaloids.” In The Alkaloids: Chemistry and Biology, Knölker, H.-J., Ed.; Academic Press: Cambridge 2023; Ch. 3, pp. 159-206.

“Total Synthesis of (-)-Voacinol and (-)-Voacandimine C.” Flynn, K. M.; Myeong, I.-S.; Pinto, T.; Movassaghi, M. J. Am. Chem. Soc. 2022, 144, 9126–9131.

“Total Synthesis and Stereochemical Assignment of (–)-Psychotridine.” Scott, T. Z.; Armelin, V. F.; Movassaghi, M. Org. Lett. 2022, 24, 2160–2164.

“Total Synthesis of Himastatin.” D’Angelo, K.; Schissel, C.; Pentelute, B.; Movassaghi, M. Science 2022, 375, 894–899.

“Structure and Function of NzeB, a Versatile C–C and C–N Bond Forming Diketopiperazine Dimerase.” Shende, V. V.; Khatray, Y.; Newmister, S. A.; Sanders, J.; Lindovska, P.; Yu, F.; Doyon, T.; Houk. K. N.; Movassaghi, M.; Sherman, D. H. J. Am. Chem. Soc. 2020, 142, 17413–17424.

“n→π* Interactions modulate the disulfide reduction potential of epidithiodiketopiperazines.” Kilgore, H. R.; Olsson, C. R.; D’Angelo, K. A.; Movassaghi, M.; Raines, R. T. J. Am. Chem. Soc. 2020, 142, 15107–15115.

“Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization.” Olsson, C. R.; Payette, J. N.; Cheah, J. H.; Movassaghi, M. J. Org. Chem. 2020, 85, 4648-4662.

“Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives.” Pompeo, M. M.; Cheah, J. H.; Movassaghi, M. J. Am. Chem. Soc. 2019, 141, 14411-14420.

“Mechanism of Permanganate Promoted Dihydroxylation of Complex Diketopiperazines: Critical Roles of Counter-Cation and Ion-Pairing.” Haines, B. E.; Nelson, B. M.; Grandner, J. M; Kim, J.; Houk, K. N; Movassaghi, M.; Musaev, D. G. J. Am. Chem. Soc. 2018, 140 (41), 13375–13386.

“Concise Synthesis of (–)-Hodgkinsine, (–)-Calycosidine, (–)-Hodgkinsine B, (–)-Quadrigemine C, and (–)-Psycholeine via Convergent and Directed Modular Assembly of Cyclotryptamines.” Lindovska, P.; Movassaghi, M. J. Am. Chem. Soc. 2017 139 (48), 17590-17596.

“Quantitative Modeling of Bis(pyridine)silver (I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates.” Bischoff, A. J.; Nelson, B. M.; Niemeyer, Z. L.; Sigman, M. S.; Movassaghi, M. J. Am. Chem. Soc. 2017, 139 (43), 15539-15547.

“Enantioselective Total Synthesis of (–)-Deoxoapodine.” Kang, T.; White, K. L.; Mann, T. J.; Hoveyda, A. H.; Movassaghi, M. Angew. Chem. Int. Ed. 2017, 56, 13857

“Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis.” Antropow, A. H.; Xu, K.; Buchsbaum, R. J.; Movassaghi, M. J. Org. Chem. 2017, 82, 7720-7731.

“Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine Via Late-Stage Oxidation of (+)-Fendleridine Derivatives.” White, K. L.; Movassaghi, M. J. Am. Chem. Soc. 2016, 138, 11383-11389.

“Convergent and Biomimetic Enantioselective Total Synthesis of (−)-Communesin F.” Lathrop, S. P.; Pompeo, M.; Chang, W.-T. T.; Movassaghi, M. J. Am. Chem. Soc. 2016, 138, 7763-7769.

“Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A.” Loach, R. P.; Fenton, O. S.; Movassaghi, M. J. Am. Chem. Soc. 2016, 138, 1057-1064.

“The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis.” Xu, K.; Tian, X.; Oh, S. Y.; Movassaghi, M.; Naber, S. P.; Kuperwasser, C.; Buchsbaum, R. J. Breast Cancer Res. 2016, 18, 14.

“Direct Observations of Intermediates Involved in the Bischler-Napieralski Reaction.” White, K. L.; Mewald, M.; Movassaghi, M. J. Org. Chem. 2015, 80, 7403-7411.

“Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids.” Kim, J.; Movassaghi, M. Acc. Chem. Res. 2015, 48, 1159-1171.

“Concise and Enantioselective Total Synthesis of (−)-Mehranine, (−)-Methylenebismehranine, and Related Aspidosperma Alkaloids.” Mewald, M.; Medley, J. W.; Movassaghi, M. Angew. Chem. Int. Ed. 2014, 53, 11634-11639.

“Application of Diazene-Directed Fragment Assembly to the Total Synthesis and Stereochemical Assignment of (+)-Desmethyl-meso-chimonanthine and Related Heterodimeric Alkaloids ” Lathrop, S. P.; Movassaghi, M. Chem. Sci. 2014, 5, 333-340.

“Synthesis and Anticancer Activity of all known (−)-Agelastatin Alkaloids.” Han, S.; Siegel, D. S.; Morrison, K. C.; Hergenrother, P. J.; Movassaghi, M. J. Org. Chem. 2013, 78, 11970-11984.

“Concise Total Synthesis of (+)-Bionectins A and C” Coste, A.; Kim, J.; Adams, T. C.; Movassaghi, M. Chem. Sci. 2013, 4, 3191-3197.

“Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids ” Boyer, N.; Morrison, K. C.; Kim, J.; Hergenrother, P. J.; Movassaghi, M. Chem. Sci. 2013, 4, 1646-1657.

“A Concise and Versatile Double-Cyclization Strategy for the Highly Stereoselective Synthesis and Arylative Dimerization of Aspidosperma Alkaloids.” Medley, J. W.; Movassaghi, M. Angew. Chem. Int. Ed. 2012, 51, 4572-4576.

“Concise Total Synthesis and Stereochemical Revision of (+)-Naseseazines A and B: Regioselective Arylative Dimerization of Diketopiperazine Alkaloids.” Kim, J.; Movassaghi, M. J. Am. Chem. Soc. 2011, 133, 14940-14943.

“Directed Heterodimerization: Stereocontrolled Assembly via Solvent-Caged Unsymmetrical Diazene Fragmentation.” Movassaghi, M.; Ahmad, O. K.; Lathrop, S. P. J. Am. Chem. Soc. 2011, 133, 13002-13005.

“Concise Total Synthesis and Stereochemical Revision of all (−)-Trigonoliimines.” Han, S.; Movassaghi, M. J. Am. Chem. Soc. 2011, 133, 10768-10771.

“General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A.” Kim, J.; Movassaghi, M. J. Am. Chem. Soc. 2010, 132, 14376-14378.

“Total Synthesis of All (–)-Agelastatin Alkaloids.” Movassaghi, M.; Siegel, D. S.; Han, S. Chemical Science 2010, 1, 561-566.

“Total Synthesis of (-)-Himandrine.” Movassaghi, M.; Tjandra, M.; Qi, J. J. Am. Chem. Soc. 2009, 131, 9648-9650.

“Total Synthesis of (+)-11,11′-Dideoxyverticillin A.” Kim, J.; Ashenhurst, J. A.; Movassaghi, M. Science 2009, 324, 238-241.

“Stereospecific Palladium-Catalyzed Entry to Monoalkyl Diazenes for Mild Allylic Reduction.” Movassaghi, M.; Ahmad, O. K. Angew. Chem. Int. Ed. 2008, 47, 8909-8912.

“Concise Total Synthesis of (+)-WIN 64821 and (–)-Ditryptophenaline.” Movassaghi, M.; Schmidt, M. A.; Ashenhurst, J. A. Angew. Chem. Int. Ed. 2008, 47, 1485-1487.

“Efficient and Stereoselective Dimerization of Pyrroloindolizine Derivatives Inspired by a Hypothesis for the Biosynthesis of Complex Myrmicarin Alkaloids.” Movassaghi, M.; Ondrus, A. E.; Chen, B. J. Org. Chem. 2007, 72, 10065-10074.

“Direct Synthesis of Pyridine Derivatives.” Movassaghi, M.; Hill, M. D.; Ahmad, O. K. J. Am. Chem. Soc. 2007, 129, 10096-10097.

“Concise Total Synthesis of (–)-Calycanthine, (+)-Chimonanthine, and (+)-Folicanthine.” Movassaghi, M.; Schmidt, M. A. Angew. Chem. Int. Ed. 2007, 46, 3725-3728.

“Stereoselective Intermolecular Formal [3+3] Cycloaddition Reaction of Cyclic Enamines and Enones.” Movassaghi, M.; Chen, B. Angew. Chem. Int. Ed. 2007, 46, 565-568.

“Single-Step Synthesis of Pyrimidine Derivatives.” Movassaghi, M.; Hill, M. D. J. Am. Chem. Soc. 2006, 128, 14254-14255.

“Enantioselective Total Synthesis of (–)-Acylfulvene and (–)-Irofulven.” Movassaghi, M.; Piizzi, G.; Siegel, D. S.; Piersanti, G. Angew. Chem. Int. Ed. 2006, 45, 5859-5863.

“Total Synthesis and Absolute Stereochemical Assignment of (+)- and (–)-Galbulimima Alkaloid 13.” Movassaghi, M.; Hunt, D. K.; Tjandra, M. J. Am. Chem. Soc. 2006, 128, 8126-8127.